CCR5 Antikörper (AA 6-20)

Produktnummer ABIN265000

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CCR5 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CCR5 Antikörper (AA 6-20) (ABIN265000)

Target: CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCR5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CCR5 Antikörper

Bindungsspezifität: AA 6-20

Spezifität: This antibody reacts to CCR5 (6-20) (CD195).

Aufreinigung: Antigen Immunoaffiinity Chromatography

Immunogen: Synthetic peptide corresponding to amino acids 6 to 20 of Human CCR5.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 0.25 to 0.5 μg/mL. Detects an approximately 40 kDa band in THP-1 whole celllysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline solution containing 0.02 % Sodium Azide as a preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: The antibody can be shipped at ambient temperature. Store (in aliquots) at 2-8 °C.

Details zu CCR5

Target: CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

Andere Bezeichnung: CD195 / CCR5

Hintergrund: Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors1,2. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells3,4. CCR5 is required for the infection by HIV-1, HIV-2, and SIV1,2. The b-chemokines RANTES, MIP-1a and MIP-1b are the ligands for CCR5 and prevent infection by M-tropic HIV-13-5. CXC5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells6,7. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites8. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.Synonyms: C-C CKR-5, C-C chemokine receptor type 5, CC-CKR-5, CCR-5, CHEMR13, CMKBR5, HIV-1 fusion coreceptor

Gen-ID: 1234

NCBI Accession: NP_000570

UniProt: P51681

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size